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Here we show that nicotine activates glucagon-like peptide-1 (GLP-1) neurons in the nucleus tractus solitarius (NTS). A growing body of preclinical evidence indicates that glucagon-like peptide-1 (GLP-1) receptor agonists reduce drug reinforcement. In mice lacking the MCH gene the prominent phenotype is hypophagia (reduced desire for food intake) and lean body mass.
The antidiabetic drugs sitagliptin and exenatide which inhibit GLP-1 breakdown and stimulate GLP-1 receptors respectively decreased nicotine intake in mice. Conversely Glp1r knockout mice consumed greater quantities of nicotine than wild-type mice. Tobacco smokers titrate their nicotine intake to avoid its noxious effects sensitivity to which may influence vulnerability to tobacco dependence yet mechanisms of nicotine avoidance are poorly understood.
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